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LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity

ABSTRACT: In this study, we performed RNA-seq to seek lncRNAs which changed significantly on expression in RAW264.7 cells before and after vesicular stomatitis virus (VSV) infection. For further investigation, we used iCLIP-seq technologies to identify the exact interaction sites between TDP43 protein and long non-coding RNA malat1 in mouse macrophages.

ORGANISM(S): Mus musculus

PROVIDER: GSE134032 | GEO | 2020/06/10

REPOSITORIES: GEO

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LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity

Project description:LncRNA Malat1 inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity

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LncRNA <i>Malat1</i> inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity.

Project description: Not available

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Differential Gene expression in the mouse mammary tumors of PyMT-Malat1 wild-type (WT), PyMT-Malat1 knockout (KO) and PyMT-Malat1 knockout with Malat1 transgene expression (TG)

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Sexual dimorphism in ALS-linked TDP43 mice

Project description:TDP43 mice study

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