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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE134125 | GEO | 2019/08/01

REPOSITORIES: GEO

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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1.

Project description: Not available

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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1

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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1 [RNA-seq & Ribo-seq]

Project description:We demonstrate that global effects of TRIM71 on the cellular transcriptome of mouse embryonic stem cells (mESCs) are largely attributable to its RNA binding activity. We observe that target repression by TRIM71 in mESCs occurs predominantly through transcript degradation. We identify a core set of targets consistently regulated by TRIM71 in different human and mouse cell lines.

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