BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of Snail

ABSTRACT: The puropose of this study is to reveal a noncanonical post-transcriptional regulatory function of BRD4 that maintains cancer growth and dissemination, with immediate translational implication for treating metastatic malignancies with clinically available bromodomain inhibitors. The next-generation RNA sequencing was used to confirm the transcriptom overlapping change after BRD4 and Snail knockout separately.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134150 | GEO | 2022/07/01

REPOSITORIES: GEO