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Natural killer cells suppress T cell tumor immune evasion [Supernatant treated control or Jak1 sgRNA B16-F10 RNA Seq]

ABSTRACT: Investigation of the transcriptional response in Jak1 depleted tumor cells upon NK-derived cytokine presence using 3’ RNA sequencing

ORGANISM(S): Mus musculus

PROVIDER: GSE134264 | GEO | 2019/07/16

REPOSITORIES: GEO

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Natural killer cells suppress T cell tumor immune evasion [Supernatant treated control or Jak1 sgRNA B16-F10 RNA Seq]

Project description:Natural killer cells suppress T cell tumor immune evasion [Supernatant treated control or Jak1 sgRNA B16-F10 RNA Seq]

| PRJNA554592 | ENA

Natural killer cells suppress T cell tumor immune evasion [NK treated B16-F10 RNA Seq]

Project description:Investigation of the tumor transcriptional response upon NK cell attack using 3’ RNA sequencing

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Natural killer cells suppress T cell tumor immune evasion [B16-F10 CRISPR/Cas9 MHC I low]

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Natural killer cells suppress T cell tumor immune evasion [B16-F10 CRISPR/Cas9 NK cell screen]

Project description:Investigation of tumor genes which limit sensitivity to killing by NK cells through a genome-wide in vitro CRISPR/Cas9 screen

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Natural killer cells suppress T cell tumor immune evasion

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-07-16 | GSE134265 | GEO

Natural killer cells suppress T cell tumor immune evasion [NK treated B16-F10 RNA Seq]

Project description:Natural killer cells suppress T cell tumor immune evasion [NK treated B16-F10 RNA Seq]

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Project description:Natural killer cells suppress T cell tumor immune evasion [B16-F10 CRISPR/Cas9 MHC I low]

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Transcription profiling of human JAK1 wild-type and JAK1 mutation-positive T cell acute lymphoblastic leukemia blasts

Project description:Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoid cell precursor proliferation, survival, and differentiation. Somatic mutations in JAK1 occur in individuals with acute lymphoblastic leukemia (ALL). JAK1 mutations were more prevalent among adult subjects with the T cell precursor ALL, where they accounted for 18% of cases, and were associated with advanced age at diagnosis, poor response to therapy, and overall prognosis; We used microarray to compare the gene expression profile of JAK1 mutation positive or negative ALL blasts Experiment Overall Design: Thawed or freshly isolated T-ALL cells (>90% blasts) were homogenized, total RNA was extracted and hybridized on Affymetrix microarrays

2009-10-02 | E-GEOD-18239 | biostudies-arrayexpress

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