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Inflammatory Cytokines shape a Changing DNA Methylome in Monocytes Mirroring Disease Activity in Rheumatoid Arthritis (in vitro)

ABSTRACT: Genome wide DNA methylation profiling of CD11b+CD33+ cells after treatment with different cytokines. The Illumina Infinium MethylationEPIC Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpGs in CD11b+CD33+ cells isolated from PBMCs treated in vitro for 4 days with TNF-alpha, IFN-alpha, IFN-gamma or control.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134425 | GEO | 2019/12/31

REPOSITORIES: GEO

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Inflammatory Cytokines shape a Changing DNA Methylome in Monocytes Mirroring Disease Activity in Rheumatoid Arthritis (patients)

Project description:Genome wide DNA methylation profiling of monocytes from healthy donors and rheumatoid arthritis patients. The Illumina Infinium MethylationEPIC Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpGs in CD11b+CD33+CD15neg monocytes isolated from PBMCs of 17 healthy donors and 47 rheumatoid arthritis patients with different disease activity scores (DAS28).

2019-12-31 | GSE134429 | GEO

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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology

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ELOVL2 is a novel tumor suppressor attenuating tamoxifen resistance in breast cancer via suppressing the AKT pathway [methylation 850K]

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DNA methylation of diabetic and normal human limbal epithelial cells

Project description:Genome wide DNA methylation profiling of primary cultures of normal and diabetic corneolimbal epithelial cells. The Illumina Infinium MethylationEPIC Human DNA methylation Beadchip v1.0 B4 was used to obtain DNA methylation profiles across approximately 850,000 CpGs.

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Genomic Evaluation of Multiparametric Magnetic Resonance Imaging -visible and -nonvisible Lesions in Clinically Localized Prostate Cancer

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2018-12-01 | GSE101908 | GEO

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Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy

Project description:DNA methylation progiling of circulaing cell-free DNA isolatated from serum of 12 MTLE patients and 11 healthy controls. The Illumina Infinium MethylationEPIC Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpGs.

2023-01-11 | GSE208758 | GEO

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