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The function of the Hedgehog signaling pathway in colonic adenomagenesis

ABSTRACT: The morphogen Indian Hedgehog plays a very important role during intestinal embryogenesis, but also maintains homeostasis in the adult gut. Intestinal Hedgehog is expressed by the intestinal epithelium and signals in paracrine manner to fibroblasts in the stromal compartment. We studied the stromal changes upon simultaneous homozygous deletion of Ihh and the tumor-suppressor gene Apc in the colon.

ORGANISM(S): Mus musculus

PROVIDER: GSE134469 | GEO | 2019/10/01

REPOSITORIES: GEO

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