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Colonic CD8 T Cell Topography in IBD revealed by Single-Cell Profiling

ABSTRACT: 10x Chromium 5' single cell RNA-Seq and VDJ sequencing of colonic CD8+ T cell cell populations in health and Ulcerative Colitis in human patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134649 | GEO | 2022/07/01

REPOSITORIES: GEO

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Single-cell profiling reveals Colonic CD8 Topography in IBD

Project description:Aims: Single-cell transcriptomic analysis of CD8 T cells in colonic tissue in Health and Ulcerative Colitis Results: We demonstrated significant heterogeneity within the CD8 population, defined disease associated populations and traced lineage relationships between different T cell subtypes

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Composition of the Colonic Mesenchyme and the Nature of its Plasticity in Inflammatory Bowel Disease

Project description:10x Chromium single cell RNA-Seq of colonic mesenchyme cell populations in health and Ulcerative Colitis in human patients and health in DSS-induced colitis in murine colon

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