Transcriptomic analysis of Tregs from RelB-dDC mice

ABSTRACT: We report here the effect of RelB ablation in CD11c+ cells on the Treg compartment accross various organs.This mice have been backcrossed to a Foxp3 reporter mouse line to enable cell sorting of Tregs with a high purity. Interestingly, RelB ablation in DCs leads to a substantial accumulation of Tregs and these Tregs show a 'tissue Treg' signature including high expression levels of KLRG1, I1LRL1 and Gata3 when compared to Tregs of littermate control mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE134779 | GEO | 2019/09/11

REPOSITORIES: GEO