A Central Role for PRC1 in Shaping the 3D Nuclear Landscape

ABSTRACT: 1. Loss of RING1B substantially disrupts nuclear architecture. 2. PRC1 mediated looping can occur at a Mb scale and is independent of CTCF. 3. Polycomb mediated looping is driven by canonical PRC1 complexes. 4. Trimeric PRC1-mediated interactions occur in vitro and in vivo. 5. Gene up-regulation does not directly lead to the loss of PRC1 loops.

ORGANISM(S): Mus musculus

PROVIDER: GSE134826 | GEO | 2019/12/15

REPOSITORIES: GEO