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Estrogen deprivation triggers and immunosuppressive phenotype in breast cancer cells

ABSTRACT: Our study reveals that while antiestrogen therapies effectively limit tumor growth in ER-positive breast cancers, they also trigger a transcriptional program that favors immune evasion.

ORGANISM(S): Homo sapiens

PROVIDER: GSE134938 | GEO | 2019/07/27

REPOSITORIES: GEO

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Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells

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BRCA1-mimetic compound NSC35446.HCl inhits IKKB expression by reducing estrogen receptor alpha occupancy in the IKKB promoter and inhibts NF-κB activity in anti-estrogen resitant human breast cells

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