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Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE135006 | GEO | 2020/06/10

REPOSITORIES: GEO

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Conditional expression of PfAP2-G for controlled massive sexual conversion in <i>Plasmodium falciparum</i>.

Project description: Not available

| S-EPMC7286680 | biostudies-literature

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum [array]

Project description:Malaria transmission requires the conversion of some asexual parasites into sexual forms termed gametocytes. The initial stages of sexual development, including sexually-committed schizonts and sexual rings, remain poorly characterized, in part because only a subset of parasites undergo sexual development and they are morphologically identical to their asexual counterparts. Here we present a system based on conditional expression of PfAP2-G, the master regulator of sexual conversion, for controlled sexual induction. Induction resulted in ~90% sexual conversion, which enables the characterization of early sexual stages without further purification. Transcriptomic analysis identified the alterations that follow pfap2-g activation, including identification of genes that are down-regulated. We also show that the inducible system enables the characterization of committed stages at the phenotypic level. Altogether, the inducible lines will facilitate the study of the initial stages of sexual development, which is important for the development of new strategies to stop malaria transmission.

2020-06-10 | GSE135005 | GEO

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum. [ChIP-Seq]

2020-06-10 | GSE135002 | GEO

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum

Project description:Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum

| PRJNA557124 | ENA

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum [array]

Project description:Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum [array]

| PRJNA557126 | ENA

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum. [ChIP-Seq]

Project description:Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum. [ChIP-Seq]

| PRJNA557120 | ENA

Roles of PfAP2-EXP2 in Plasmodium falciparum blood-stage development

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-02 | GSE180438 | GEO

The Transcription Factor PfAP2-O Influences Virulence Gene Transcription and Sexual Development in <i>Plasmodium falciparum</i>.

Project description: Not available

| S-EPMC8275450 | biostudies-literature

Plasmodium falciparum infection

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-15 | E-GEOD-35936 | biostudies-arrayexpress

PfAP2-O Influences Virulence Gene Transcription and Sexual Development in Plasmodium falciparum

Project description:The project examined the function of the putative transcription factor PfAP2-O from Plasmodium falciparum. This factor besides an essential function in sexual stages also influences variant, virulence associated genes. In a pull down analysis, HA-tagged PfAP2-O was immunoprecipitated and proteins assoaciated were analysed and three differentially appearing protein bands were analysed.

2021-06-28 | PXD026237 | Pride

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