Bach2 deficiency leads to spontaneous expansion of IL-4-producing T follicular helper cells and autoimmunity

ABSTRACT: The transcription factor Bach2 is a critical negative regulator of Tfh cell differentiation, especially IL-4 subset. Tfh cells from the mesenteric lymph nodes of WT and Bach2 CD4 conditional KO mice were collected to process the Rna-seq. Mechanistically, Bach2 may limit abnormal IL-4-produicng Tfh cell formation by repressing c-Maf, CXCR5 and IL-4.

ORGANISM(S): Mus musculus

PROVIDER: GSE135087 | GEO | 2021/01/26

REPOSITORIES: GEO