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SETD2-mediated loss of a panel of miRNAs determines MAPK/JNK signaling pathway activation and multidrug resistance in renal cell carcinoma

ABSTRACT: Finding the downstream miRNAs of SETD2 in the renal cell carcinoma cell line the coordinated expression of SETD2-miRNAs-MAPK/JNK may be predictive of poor prognostic in patients with RCC. Our findings also emphasize the therapeutic potential of MAP4K4 in RCC therapy and support the development of an effective therapeutic strategy to target MAP4K4 by molecularly targeted approaches

ORGANISM(S): Homo sapiens

PROVIDER: GSE135105 | GEO | 2019/07/31

REPOSITORIES: GEO

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RNA-seq analysis of A498 cell line treated with siSETD2 or si-NC

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Project description:Setd2 knockdown.

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