Transcriptomic response to Keap1-specific electrophile modification in zebrafish embryos

ABSTRACT: Using our eletrophile delivery platform in zebrafish embryos (termed "Z-REX"), we launched a Z-REX-coupled RNA-seq screen to identify genes whose expression is significantly changed following Keap1-engagement with selective native lipid-derived electrophiles housing covalently-reactive motifs. The electrophiles tested were 4-hydroxynonenal (HNE) and 4-hydroxydodecenal (HDE).

ORGANISM(S): Danio rerio

PROVIDER: GSE135190 | GEO | 2021/08/04

REPOSITORIES: GEO