Microglial microRNAs mediate sex-specific responses to tau pathology

ABSTRACT: Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by miRNAs, but it is unknown whether microglial miRNAs have sex-specific influences on disease. We show that microglial miRNA expression differs in males and females, and loss of miRNAs leads to sex-specific changes in the microglial transcriptome and to tau pathology. These findings suggest microglial miRNAs influence tau pathogenesis in a sex-specific manner.

ORGANISM(S): Mus musculus

PROVIDER: GSE135330 | GEO | 2019/11/05

REPOSITORIES: GEO