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Gene-expression profiling in pancreatic cancer cells treated with macrophage conditioned media and etomoxir

ABSTRACT: The study aims to show that a metabolic shift is a precondition for the initiation of an invasive/metastatic program in pancreatic cancer. Paracrine cues and metabolic stress (mimicked in vitro by treatment with macrophage-conditioned media and low dose etomoxir) regularly found in the metastasis-promoting tumor stroma consistently induced transcriptional changes resulting in the acquisition of migratory and invasive abilities.

ORGANISM(S): Homo sapiens

PROVIDER: GSE135686 | GEO | 2023/08/07

REPOSITORIES: GEO

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