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Human MRC-5 cells' gene expression difference compared with that of the adult cells including CCD-1079sk and IMR90

ABSTRACT: human somatic cell MRC-5 had different gene expression level compared with that of the adult cells including CCD-1079sk and IMR90. This difference gave the human somatic cell MRC-5 unique characteristics which could then be compared with the human ES cells by genes comparison to show the gene expression difference between human somatic cells and human ES cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE13571 | GEO | 2009/04/01

SECONDARY ACCESSION(S): PRJNA113925

REPOSITORIES: GEO

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Human ES cells' gene expression difference compared with that of the adult cells including CCD-1079sk and IMR90

Project description:Human ES cells had different gene expression level compared with that of the adult cells including CCD-1079sk and IMR90. This difference gave the human ES cells unique characteristics which could then be compared with other species' ES cells or iPS cells like mouse ES cells and Rat iPS cells by the homologue genes comparison to show which species' ES cells or iPS cells were more competitive with the other.

2009-04-01 | GSE13357 | GEO

Transcriptome data for human ES, IMR90 and IMR90-derived iPS (ESIMR90) cells

Project description:Assessing relevant differences between human induced pluripotent stem (iPS) cells and human embryonic stem (ES) cells is important, given that such differences may impact their potential therapeutic use. We used microarray to profile the changes in global gene expression arising from the reprogramming of somatic cells to induced pluripotent stem cells. Comparison of gene expression between human embryonic stem cells (HES-3), induced pluripotent stem cells (ESIMR90) and its parental fibroblasts (IMR90). A pair of biololical replicates were analysed for each cell line.

2011-01-05 | E-GEOD-26453 | biostudies-arrayexpress

Homo sapiens

Project description:Human ES cells' gene expression difference compared with that of the adult cells including CCD-1079sk and IMR90

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Homo sapiens

Project description:human MRC-5 cells' gene expression difference compared with that of the adult cells including CCD-1079sk and IMR90

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Effects of Wnt3A on the transcriptome of CCD-18Co human colon fibroblasts

Project description:Purpouse: To compare the transriptome of CCD-18Co human colon fibroblasts treated with vehicle or Wnt3A. Methods: We treated triplicate plates of CCD-18Co cells with vehicle or Wnt3A during 24 h. Afterwards, we obtained total RNA and used it in RNA-seq experiments. Results: Our analysis rendered a total of 1136 differentially expressed genes (FDR<0.05), of which 662 were up-regulated and 474 were downregulated in response to Wnt3A. Conclusions: Wnt3A regulates a wide set of genes in CCD-18Co human colon fibroblasts

2017-10-30 | GSE89124 | GEO

Gene expression data from IMR90 Control, IMR90 HRAS-G12V, IMR90 HRAS-G12V+shDOT1L, IMR90 DOT1L Overexpression

Project description:Gene expression data from IMR90 Control, IMR90 HRAS-G12V, IMR90 HRAS-G12V+shDOT1L, IMR90 DOT1L Overexpression

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Transcriptome data for human ES, IMR90 and IMR90-derived iPS (ESIMR90) cells

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Phosphorylation level of SIRT1 in proliferating and senescent IMR90 cells

Project description:Mammalian SIRT1 is a central regulator of metabolism and aging. This project is to analyze global phosphorylation levels of mammalian SIRT1 in proliferating and senescence states using human lung fibroblast IMR90, in order to explore the post-translational regulation of SIRT1 protein upon cellular senescence and its potential roles in the regulatory mechanisms of SIRT1 homeostasis.

2020-09-29 | PXD020081 | Pride

RNA-seq of young and quiescent (9 days) MRC-5 human fibroblasts

Project description:Comparison of gene expression profiles of quiescent MRC-5 fibroblasts and young MRC-5 fibroblasts. Jena Centre for Systems Biology of Ageing – JenAge (www.jenage.de)

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Transcriptomic profiles in dental pulp cells from one CCD patient with allelic RUNX2 deletion and one sex-age matched unaffected individual.

Project description:The goal is to investigate the downstream targets of RUNX2 signaling which are potentially involved in the disease process of Cleidocranial Dysplasia (CCD). RNA-seq was performned to compare the mRNA profiles in human dental pulp cells from one CCD patient with allelic RUNX2 deletion (CCD-011) and sex-age matched unaffected individual(Control). Of 25,643 genes analyzed, 11,039 genes had no detectable signal in both CCD and control samples tested leaving 14,604 genes that were evaluated for differential gene expression. In the detectable genes, 60 transcripts (4.1%) were found to be statistically significantly dysregulated with 63% upregulated and 27% downregulated (fold change ≥ 2; q-value < 0.05).

2017-10-03 | GSE104527 | GEO

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