Altered 3D chromatin structure permits inversional recombination at the IgH locus

ABSTRACT: We report that in the absence of intergenic control region 1 (IGCR1), a regulatory sequence that specifies the RAG scanning domain on WT IgH alleles, VH and DH gene segments can recombine with each other by both deletion and inversion of intervening DNA.

ORGANISM(S): Mus musculus

PROVIDER: GSE135763 | GEO | 2020/07/02

REPOSITORIES: GEO