Silencing ferrochelatase in breast cancer cells MDA-MB-231

ABSTRACT: Aim was to identify novel targets of protoporphyrin-IX (PpIX) after silencing Ferrochelatase (FECH) enzyme. PpIX is a light sensitive metabolite of heme synthesis. Generation of PpIX is increased if FECH activity is suppressed. Here, silencing of FECH leads to down-regulation of PpIX, measured by a decrease of PpIX-specific fluorescence. PpIX is a photosensitizer used for photodynamic treatment of various carcinomas. Increasing PpIX leads to apoptosis of tumor cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE135845 | GEO | 2019/08/15

REPOSITORIES: GEO