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Multi-omics analysis to study hepatitis B virus-host interaction

ABSTRACT: Curing treatment for HBV infection is yet unavailable, mainly due to unmet gaps in current understanding of the details about HBV-host interaction. By quantitatively assessing HBV-induced global changes in host transcriptome, translatome and proteome, we identified multiple previously unknown transcriptional and translational events that HBV orchestrated to remodel host proteostasis networks and afford micro-environments essential for HBV proliferation and persistence.By delineating novel drug targets and biomarkers in HBV-host interaction, multi-omics interrogation may facilitate the development of next-generation therapeutics or diagnostics against HBV infection and the related maladies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE135860 | GEO | 2021/03/06

REPOSITORIES: GEO

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