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Transcriptome analysis of methylparaben treated H1299 lung carcinoma cells

ABSTRACT: Purpose: finding differential transcripts usage in environmentally harzardous chemical, methylparaben Methods: transcriptome analysis by the RNA-seq via mRNA pull-down Results: We found that methylparaben increases cellular toxicity in H1299 cells. Also, over thousands of retained intron events were detected from the RNA-seq analysis. Conclusions: Methylparaben increases cytotoxic effects in H1299 cells through the caspase-3 pathway and changes the context of trascript through the splicing regulation mechanisms.

ORGANISM(S): Homo sapiens

PROVIDER: GSE135861 | GEO | 2020/04/01

REPOSITORIES: GEO

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