Transcriptomic analyssis following EHMT1/2 inhibition

ABSTRACT: RNA was isolated from PEO1 olaparib resistant (PEO1-OR) cells grown in complete growth media or PEO1-OR clone 4 cells grown in complete growth media with 500 nanomolar of UNC0642 for 72 hrs. RNA-sequencing was performed to evaluate UNC0642-dependent transcriptional reprogramming, which contributes to resensitization of PEO1-OR to olaparib. PEO1 line was authenticated prior to sequencing. PEO1 parental were confirmed to be BRCA2-mutated (5139C>G).

ORGANISM(S): Homo sapiens

PROVIDER: GSE135864 | GEO | 2019/08/16

REPOSITORIES: GEO