Epigenetic modification of GR enhancers by SETD1A/COMPASS complex in murine macrophages

ABSTRACT: Nuclear interaction studies by ChIP coupled with mass spectrometry identified the COMPASS/SETD1A complex as interaction partner of the glucocorticoid receptor (GR) in murine bone marrow-derived macrophages (BMDMs). Here, we profiled the occupancy of SETD1A and CXXC1, two subunits of the COMPASS/SETD1A complex in murine macrophages after LPS and Dex+LPS stimulation. We show, that GR recuits SETD1A and CXXC1 to GR enhancer and that SETD1A recruitment does correlate with changes in H3K4methylation at some of those enhancers.

ORGANISM(S): Mus musculus

PROVIDER: GSE136070 | GEO | 2020/12/31

REPOSITORIES: GEO