Pathogenic LMNA variation disrupts a tissue-specific lamina-chromatin signature, resulting in loss of cellular identity

ABSTRACT: We demonstrate that a normal function of lamina-associated chromatin is to maintain silencing of undesired lineages, and laminopathies, like LMNA T10I and R541C, may specifically target these regions, resulting in predictable tissue-specific nuclear architecture changes during development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE136252 | GEO | 2021/02/01

REPOSITORIES: GEO