Enterovirus 71 oncolysis of malignant gliomas

ABSTRACT: This study finds that EV71 has oncolytic activity against experimental human malignant gliomas. RNA-seq analysis of infected glioma cells reveals transcriptional up-regulation, notably genes in apoptosis pathways. Application of virus targeting based on brain-specific microRNA-124 enhances the safety profile. Oncolysis with EV71 may be a potentially novel treatment for malignant gliomas.

ORGANISM(S): Homo sapiens

PROVIDER: GSE136330 | GEO | 2019/08/27

REPOSITORIES: GEO