Genomics

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Identification of YTHDF1 targeted m6A modified transcripts in lung cancer cells


ABSTRACT: In addition to perform the m6A-seq in A549 cells, we sequenced RNA obtained from the immuno-purified complex of YTHDF1 (RIP-seq) to reveal YTHDF1 bound mRNAs, 3,676 genes were shared (m6A-seq+RIP-seq) as high-confident targets of YTHDF1 , which were mapped to cell cycle and tumor (including lung cancer) related signaling pathways in the KEGG pathway database Overall design: The transcriptome, m6A modified transcripts, and YTHDF1 binding transcripts were identified.

INSTRUMENT(S): Illumina HiSeq 4000 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Xingyang Li  

PROVIDER: GSE136433 | GEO | 2019-09-26

REPOSITORIES: GEO

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