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Ketogenic diet activates protective γδ T cell responses against influenza virus infection

ABSTRACT: Influenza A virus (IAV) infection-associated morbidity and mortality are a key global healthcare concern, necessitating the identification of novel therapies capable of reducing the severity of IAV infections. In this study, we show that the consumption of a low-carbohydrate, high-fat ketogenic diet (KD) protects mice from lethal IAV infection and disease. KD feeding resulted in an expansion of γδ T cells in the lung that improved barrier functions, thereby enhancing anti-viral resistance. Expansion of these protective γδ T cells required metabolic adaptation to a ketogenic diet, as neither feeding mice a high-fat high-carbohydrate diet nor providing chemical ketone body substrate that bypasses hepatic ketogenesis protected against infection. Therefore, KD mediated immune-metabolic integration represents a viable avenue towards preventing or alleviating influenza disease.

ORGANISM(S): Mus musculus

PROVIDER: GSE136536 | GEO | 2019/08/29

REPOSITORIES: GEO

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Project description:Ketogenic diet activates protective γδ T cell responses against influenza virus infection

| PRJNA562635 | ENA