Activity-dependent regulome and transcriptome of human GABAergic neurons reveal new patterns of gene regulation and neurological disease heritability

ABSTRACT: Neuronal activity-dependent gene expression is essential for healthy brain development. Emerging studies implicate alterations in GABAergic neuronal circuits in neurodevelopmental and psychiatric disorders. We conducted an activity-dependent transcriptional and epigenetic profiling of human iPSC-derived GABAergic neurons.

ORGANISM(S): Homo sapiens

PROVIDER: GSE136656 | GEO | 2020/11/27

REPOSITORIES: GEO