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Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE136764 | GEO | 2019/09/04

REPOSITORIES: GEO

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Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [DNase-Seq]

Project description:Endogenous retroviruses (ERVs) and other transposons can act as tissue-specific regulators of gene expression in cis, with potential to affect biological processes. In cancer, epigenetic alterations and transcription factor misregulation may uncover the regulatory potential of typically repressed ERVs, which could contribute to tumour evolution and progression. Here, we asked whether transposons help to rewire oncogenic transcriptional circuits in acute myeloid leukaemia (AML). Using epigenomic data from both primary cells and cell lines, we have identified six ERV families that are frequently found in an open chromatin state in AML when compared to differentiated myeloid cells. A subset of these AML-associated ERVs harbour enhancer-specific histone modifications, and are bound by transcription factors that play key roles in haematopoiesis and in the pathogenesis of AML. Using CRISPR-mediated genetic and epigenetic editing, we have established causal links between ERV deregulation in AML and expression changes of adjacent genes. Finally, we show that deletion and epigenetic silencing of an ERV associated with the APOC1 gene leads to growth suppression by inducing apoptosis in leukemia cell lines. Our results suggest that ERV derepression provides an additional layer of gene regulation in AML that may be exploited by cancer cells to help drive oncogenic phenotypes.

2019-09-04 | GSE136760 | GEO

Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [RNA-Seq]

2019-09-04 | GSE136763 | GEO

Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [ChIP-Seq]

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Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia

Project description:Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia

| PRJNA563616 | ENA

Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [RNA-Seq]

Project description:Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [RNA-Seq]

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Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [ChIP-Seq]

Project description:Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [ChIP-Seq]

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Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [DNase-Seq]

Project description:Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia [DNase-Seq]

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CEBPA Dysfunction Intiates CSF3R Mutant Acute Myeloid Leukemia Through Disruption of Myeloid Lineage Enhancers

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-02 | GSE122166 | GEO

Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-10-31 | GSE186619 | GEO

Mutant NPM1 binds chromatin and directly regulates oncogenic transcription in acute myeloid leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-30 | GSE196480 | GEO

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