Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: WT vs PKI)

ABSTRACT: PGC1alpha plays an important role in energy metabolism and mitochondrial function in the heart, multiple attempts have failed to upregulate PGC1alpha expression as a therapy, with the underlying mechanism to be answered. We used RNA sequencing to detail the global programme of gene expression in the hearts of wild-type mice with or without cardiomyocyte-restricted PGC1alpha overexpression.

ORGANISM(S): Mus musculus

PROVIDER: GSE136770 | GEO | 2022/08/01

REPOSITORIES: GEO