Sestrin prevents skeletal muscle atrophy

ABSTRACT: We identify sestrins, a family of stress-inducible metabolic regulators, as protective factors against muscle wasting. Sestrin expression decreases during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin overexpression suffices to prevent atrophy.

ORGANISM(S): Mus musculus

PROVIDER: GSE136866 | GEO | 2019/09/05

REPOSITORIES: GEO