Dataset Information


A study of the transcriptional response to a single double-strand break in Bacillus subtilis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Bacillus subtilis WGS2 platform

SUBMITTER: Alan D. Grossman  

PROVIDER: GSE13694 | GEO | 2008-11-21



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Comparison of responses to double-strand breaks between Escherichia coli and Bacillus subtilis reveals different requirements for SOS induction.

Simmons Lyle A LA   Goranov Alexi I AI   Kobayashi Hajime H   Davies Bryan W BW   Yuan Daniel S DS   Grossman Alan D AD   Walker Graham C GC  

Journal of bacteriology 20081205 4

DNA double-strand breaks are particularly deleterious lesions that can lead to genomic instability and cell death. We investigated the SOS response to double-strand breaks in both Escherichia coli and Bacillus subtilis. In E. coli, double-strand breaks induced by ionizing radiation resulted in SOS induction in virtually every cell. E. coli strains incapable of SOS induction were sensitive to ionizing radiation. In striking contrast, we found that in B. subtilis both ionizing radiation and a site  ...[more]

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