Multiplex indexing approach for the detection of DNase I hypersensitive sites in single cells

ABSTRACT: We describe a novel indexing protocol that employs the activities of terminal DNA transferase and T4 DNA ligase to add unique cell barcodes to DNase-digested DNA ends. This protocol allows profiling of genome-wide DHSs in over 10,000 single-cells in an individual experiment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE136987 | GEO | 2022/08/26

REPOSITORIES: GEO