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Profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE137013 | GEO | 2019/09/07

REPOSITORIES: GEO

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miRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants.

Project description:To further understanding of miRNA expression during radioprotectation, we used microarray analysis to determine the differential expression of miRNAs in the bone marrow of mice exposed to high-dose IR with and without pretreatment with three types of radioprotectants: Amifostine (WR2721), CBLB502, and Nilestriol, as well in the hypothalamus of mice exposed to IR with and without pretreatment with amifostine. Overall, amifostine treatment led to a similar expression pattern of miRNAs to that of CBLB502 but not to that of nilestriol in bone marrow. The radioprotectants exhibited mostly opposite effects against IR-induced miRNAs. These results expand the biological function of miRNAs in mediating the activity of radioprotectants, further offering insights into the molecular mechanism underlying radioprotection.

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lncRNA and mRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

Project description:To further understanding of lncRNA and mRNA expression during radioprotectation, we used microarray analysis to determine the differential expression of lncRNAs, and mRNAs in the bone marrow of mice exposed to high-dose IR with and without pretreatment with three types of radioprotectants: Amifostine, CBLB502, and Nilestriol, as well in the hypothalamus of mice exposed to IR with and without pretreatment with amifostine. Overall, the induction of lncRNAs and mRNAs was increased by pretreatment with all three radioprotectants. Amifostine treatment led to a similar expression pattern of lncRNAs, and mRNAs to that of CBLB502 but not to that of nilestriol. The radioprotectants exhibited mostly opposite effects against IR-induced lncRNAs, and mRNAs in bone marrow, and might induce a potential common mechanism of histone gene downregulation only in the face of IR, mainly via nucleosome assembly and related signaling pathways, which may be a common response to IR-induced biological changes and could explain the radioprotection mechanism. These results expand the biological function of lncRNAs, and mRNAs in mediating the activity of radioprotectants, further offering insights into the molecular mechanism underlying radioprotection.

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Profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

Project description:Profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

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miRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants.

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