Gene expression study in SF3B1-mutated, NOTCH1-mutated and WT CLL cells

ABSTRACT: Mutations of SF3B1 in CLL induce alternative splicing in multiple transcripts, including DVL2. DVL2 in turn can act as a negative regulator of NOTCH1 signaling. Gene Expression Profile (GEP) was used to investigate the activation of the NOTCH1 pathway in presence of alternatively spliced DVL2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137024 | GEO | 2019/09/07

REPOSITORIES: GEO