Project description:PlexinD1 is an axon guidance molecule which is upregulated in neuroendocrine prostate cancer (PC). In order to better understand its role in mediating the development and disease progression in PC, we performed the RNA-seq in PC cells in lack of or with enforced PlexinD1 expression comparing to the control cells. We compared the gene expression profile and conducted downstream pathway analysis. Our data dememstrated that PlexinD1 regulates the cell lineage in castration-resistant PC by activating Gli1 signaling.
