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Developmental trajectory of pre-hematopoietic stem cell formation from endothelium (scATAC-seq data set)

ABSTRACT: To examine the cell and molecular transitions between endothelial (E), hemogenic endothelial (HE), and intra-arterial clusters (IAC) cells, we profiled ~1700 cells from the caudal arteries (dorsal aorta, umbilical, vitelline) of embryonic day (E) 10.5 mouse embryos by single-cell ATAC sequencing (scATAC-Seq). We found extensive cis--regulatory landscape change during the endothelial to hematopoietic transition (EHT).

ORGANISM(S): Mus musculus

PROVIDER: GSE137115 | GEO | 2020/04/27

REPOSITORIES: GEO

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Developmental trajectory of pre-hematopoietic stem cell formation from endothelium (scRNA-seq data set)

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Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression

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Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression II

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