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Persistent Organic Pollutants cause insulin resistance and ruin the health effects of salmon oil

ABSTRACT: Transcriptional profiling of Rat liver submitted to high fat diets made with either crude (HFC) or refined salmon oil (HFR). Keywords: transcriptomic analysis

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE13716 | GEO | 2009/11/24

SECONDARY ACCESSION(S): PRJNA110393

REPOSITORIES: GEO

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Persistent Organic Pollutants cause insulin resistance and ruin the health effects of salmon oil

Project description:Transcriptional profiling of Rat liver submitted to high fat diets made with either crude (HFC) or refined salmon oil (HFR). Keywords: transcriptomic analysis Two groups of rats were submitted to high fat diet containing either crude salmon oil (HFC) or refined salmon oil (HFR). After 28 days, livers were retrieved and RNA extracted. A pool of RNA from HFR group was used as the reference group. Each HFC was compared to reference group (pool of HFR). Five biological replicates were processed.

2010-05-19 | E-GEOD-13716 | biostudies-arrayexpress

Organic pollutants in salmon oil and health effect

Project description:Transcriptional profiling of rat adipose tissue and skeletal muscle submitted to high fat diets made with either crude (HFC) or refined salmon oil (HFR). Keywords: transcriptomic analysis

2018-04-20 | GSE14968 | GEO

Transcriptional response of Atlantic salmon (Salmo salar) to fish oil vs vegetable oil based diets

Project description:The effect of different diets (i.e. fish oil based vs vegetable oil based) on liver transcription profiles over the life history stages (freshwater and marine phases) of cultured Atlantic salmon (Salmo salar) were explored. Two groups of fish were raised from first feeding on different lipid containing diets; a) the standard 100% fish oil based diet, the other enriched with a blend of vegetable oils (75%) + fish oil (25%). Liver samples were taken from fish at four time points: two freshwater phase (as parr 36 weeks post hatch (wph); as pre-smolts, 52 wph) and two marine phase ( as post-smolts 55 wph; and as adult fish , 86 wph). A total of 96 cDNA microarray hybridisations - TRAITS / SGP Atlantic salmon 17k feature cDNA microarray - were performed ( 2 diets x 4 time points x 6 biological replicates x 2 -dye swap) using a comon pooled reference contol design.

2008-08-01 | E-TABM-449 | biostudies-arrayexpress

Novel roles for NKX family members and innate immunity genes in cardiac remodeling

Project description:Here we used RNAseq in juvenile pink salmon (Oncorhynchus gorbuscha) exposed to crude oil at different concetrations to identify molecular changes associated with cardiac defects.

2018-08-10 | GSE102654 | GEO

Transcription profiling of Atlantic salmon following dietary substitution of fish oil with vegetable oils

Project description:There is an increasing drive to replace fish oil (FO) in finfish aquaculture diets with vegetable oils (VO), driven by the short supply of FO derived from wild fish stocks. Little is known of the consequences for fish health after such substitution. The effect of dietary VO on hepatic gene expression was determined in Atlantic salmon (Salmo salar) byg a cDNA microarray analysis. Post-smolt farmed salmon were reared for x weeks on diets where the FO component of the feed was replaced with one of three different VOs - rapeseed (RO), soybean (SO) or linseed (LO). RNA from five fish fed on each diet was extracted. A total of 20 cDNA microarray hybridisations - TRAITS / SGP Atlantic salmon 17k feature cDNA microarray - were performed - 4 diets (three VO + FO control) x 5 individuals - using a common pooled reference control design. Data were obtained from 19 of the 20 hybridisations.

2008-10-27 | E-TABM-478 | biostudies-arrayexpress

Responses of Atlantic salmon to vaccination and challenge with salmon alphavirus (SAV) and Moritella viscosa

Project description:Salmon alphavirus (SAV) and Moritella viscosa causing respectively pancreatic disease and winter ulcer are among the most important pathogens threatening Atlantic salmon aquaculture. Fish is protected by vaccination with different rate of success. Here, responses to vaccination were assessed followed with pathogen challenges of vaccinated salmon and saline injected control.

2021-04-23 | GSE173130 | GEO

Genotype-specific responses in intestinal lipid metabolism to complete dietary fish oil replacement by vegetable oil in Atlantic salmon

Project description:As part of a study investigating the effects of genotype on responses to sustainable feeds in Atlantic salmon, a microarray analysis of the intestine transcriptome of two family groups, identified as 'Lean' or 'Fat' (based on flesh lipid content), which were fed a diet containing either 100% fish oil (FO) or 100% vegetable oil (VO) was undertaken.

2012-03-01 | E-TABM-1173 | biostudies-arrayexpress

RNAseq of farmed and wild Atlantic salmon fed vegetable oil or fish oil or phospholipid diet from first feeding

Project description:Farmed and wild Atlantic salmon was given either vegetable oil (low DHA and EPA) feed or fish oil (high in DHA and EPA) feed or phospholipid (high in phospholipid) feed from start of feeding. We sampled and RNAseq two tissues (pyloric caeca and liver) on day 0, day 48, day 65 and day 94 after initial feeding.

2019-10-30 | E-MTAB-8306 | biostudies-arrayexpress

Genotype-specific responses in hepatic lipid metabolism to complete dietary fish oil replacement by vegetable oil in Atlantic salmon

Project description:As part of a study investigating the effects of genotype on responses to sustainable feeds in Atlantic salmon, a microarray analysis of the liver transcriptome of two family groups, identified as 'Lean' or 'Fat' (based on flesh lipid content), which were fed a diet containing either 100% fish oil (FO) or 100% vegetable oil (VO) was undertaken. Cholesterol and lipoprotein metabolism pathways that were differentially affected by diet depending on the genetic background of the fish were identified.<br><br>The TRAITS/SGP (v.2.1) salmon 17k cDNA microarray was used in this experiment. A dual-labelled experimental design was employed for the microarray hybridisations. aRNA from each experimental sample (Cy3 labelled) was competitively hybridised against a common pooled-reference sample (Cy5 labelled), which comprised equal amounts of aRNA from each of the samples used in the study. This design permits valid statistical comparisons across all treatments to be made. The entire experiment comprised 24 hybridisations - 2 lipid phenotypes (Lean/Fat) × 2 diets (FO/VO) × 6 biological replicates.

2011-01-04 | E-TABM-1089 | biostudies-arrayexpress

crude oil metagenome

Project description:Crude oil Metagenome

| PRJNA263752 | ENA