Genomics

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3D chromatin structure in colon cancer


ABSTRACT: We report the application of in situ Hi-C technology to 40 colorectal cancer patients and 10 paried-normal tissue to indentify CRC specific changes in 3D chromatin structure. The chromatin contact matrix were generated by the sequencing data and image processing/deep learning-based algorithm was proposed to identify long-range abnormal chromatin interaction patterns in the contact matrix. The tumor specific 3D chromatin sturcutre changes and the enhancer-promoter rewiring mediated by the identified chromatin sturcture changes were analyzed. The complex chromosome-wide rearrangements such as chromothripsis and its effect to 3D chromatin sturucters were also observed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137188 | GEO | 2023/07/27

REPOSITORIES: GEO

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