Failed apoptosis enhances melanoma cancer cells aggressiveness

ABSTRACT: Recent evidence shows that partial mitochondrial permeabilization and non-lethal caspase activation occur under certain circumstances, though it remains unclear how failed apoptosis impacts established cancers. Using a cancer cell model to trigger non-lethal caspase activation based on either BH3-only protein expression or chemotherapy treatment, we found that melanoma cancer cells failing to undergo complete apoptosis have a particular transcriptomic signature associated with focal adhesions, transendothelial migration and modifications of actin cytoskeleton.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137278 | GEO | 2020/05/02

REPOSITORIES: GEO