Bimodal Adenine and Cytosine CRISPR Base Editing on DNA

ABSTRACT: Adenine and cytosine base editors (ABEs and CBEs) represent a new genome editing technology that allows the programmable installation of A-to-G or C-to-T alterations on DNA. We engineered Streptococcus pyogenes Cas9-based adenine and cytosine base editor (SpACE) that enables efficient simultaneous introduction of A-to-G and C-to-T substitutions in the same base editing window on DNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137411 | GEO | 2020/07/02

REPOSITORIES: GEO