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Next-gen sequencing for transcriptomic differences in livers of mice with acetaminophen toxicity

ABSTRACT: The goal of the study is to compare transcriptome profile of mouse liver with acetaminophen toxicity to potentially therapeutic healthy blood serum exosome or cytokine treatments along with acetaminophen Studies also included sequencing of miRNA from exosomes isolated from pooled serum of several healthy anonimous human donors and livers of mice that received the exosome treatment along with acetominophen.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE137587 | GEO | 2019/09/18

REPOSITORIES: GEO

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Next-gen sequencing for miRNA content of exosomes and hepatocytes in mice with acetaminophen toxicity

Project description:Micro RNA content of extracellular vesicles/exosomes may serve as a marker of certain pathophysiological conditions. We report differential expression of micro RNA in exosomes isolated from mouse blood or medium of cultured primary mouse hepatocytes versus parental hepatocytes or whole liver. Studies included exosomes from blood of mice or medium of cultured primary hepatocytes with acetaminophen toxicity as well as a potentially therapeutic cytokine with acetaminophen.

2019-12-02 | GSE77554 | GEO

Characterization of serum small extracellular vesicles and their small RNA contents across human, rat, and mouse

Project description:In the present study, the isolated serum exosomes from healthy adults, rats and mice were comparatively characterized; the small RNA compositions were analyzed; the serum exosome miRNA profiles and exosome depleted serum miRNA profiles were obtained by small RNAseq, and the distributions of miRNA component inside and outside of the serum exosomes were also compared.

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Characterization of serum small extracellular vesicles and their small RNA contents across human, rat, and mouse (data for rat and mouse)

Project description:In the present study, the isolated serum exosomes from healthy adults, rats, and mice were comparatively characterized; the small RNA compositions were analyzed; the serum exosome miRNA profiles and exosome depleted serum miRNA profiles were obtained by small RNAseq, and the distributions of miRNA component inside and outside of the serum exosomes were also compared.

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Next-gen sequencing for transcriptomic differences in HuH-7 human hepatocellular carcinoma cell line models of hepatotoxicity

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Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity

2013-06-08 | GSE37874 | GEO

Next-gen sequencing for transcriptomic differences in livers of mice with acetaminophen toxicity

Project description:Next-gen sequencing for transcriptomic differences in livers of mice with acetaminophen toxicity

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Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity

Project description:Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were treated with either saline (PBS) or 100mg/kg APAP. Liver RNA was harvested eight hours after challenge and processed for microarray analysis. Comparison of 2 treatment conditions in 2 genotypes, biological replicates in triplicate.

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Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples

2015-11-04 | GSE74000 | GEO

Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples

Project description:In this study we conducted transcriptomics analyses of: (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (n=3) and from healthy livers (n=2) and (ii) hepatic cell systems exposed to acetaminophen, including their respective vehicle controls. The investigated in vitro systems are: HepaRG cells, HepG2 cells and a novel human skinpostnatal stem cell-derived model i.e. human skin-precursors-derived hepatocyte-like cells (hSKP-HPC). Clinical samples were obtained after surgical removal of the explant liver of patients diagnosed with ALF due to acetaminophen intoxication and treated by orthotopic liver transplantation (n=3). Samples from healthy livers were obtained from individuals deceased from brain damage (n=2). Different samples of hSKP, HepG2 and HepaRG were obtained from the same cell batch of each cell system. All cells were exposed for 24 hours to their corresponding sub cytotoxic concentrations (IC10): IC10(hSKP-HPC)=18mM; IC10(HepaRG)=13mM; IC10(HepG2)=2mM. Experiments were conducted in triplicate. This dataset is part of the TransQST collection.

2015-11-04 | E-GEOD-74000 | biostudies-arrayexpress

The Protective Role of the Epitranscriptome against Acetaminophen Toxicity

Project description:We report differential mRNA sequencing data on C57BL/6 background of both Wildtype and Alkbh8Def in saline and acetaminophen exposure conditions in acute (6 hour) and chronic (4 day) conditions.

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