The global IL-1α gene expression response in p65 enhancer mutant HeLa cells.

ABSTRACT: Conversion of cytokine-driven changes in chromatin topology into gene regulatory circuits during inflammation still remains unclear. Here, we analyzed the expression profiles of HeLa cells carrying microdeletions of p65-binding sites in two enhancers regulating the IL-1α-inducible IL8 and CXCL1-3 genes within the extended chemokine locus on human chromosome 4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137589 | GEO | 2019/09/18

REPOSITORIES: GEO