Genomics

Dataset Information

95

Breast cancer / tamoxifen monotherapy (microdissected tumor biopsies)


ABSTRACT: dataset of 60 patients with ER-positive primary breast cancer and treated with tamoxifen monotherapy for 5 years. Data were generated from LCMed cancer cells. Sample_keyword: breast cancer, tamoxifen, recurrence Keywords: other

INSTRUMENT(S): Arcturus 22k human oligonucleotide microarray

SUBMITTER: Xiao-Jun Ma  

PROVIDER: GSE1378 | GEO | 2004-06-07

SECONDARY ACCESSION(S): PRJNA90027

REPOSITORIES: GEO

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Publications


Tamoxifen significantly reduces tumor recurrence in certain patients with early-stage estrogen receptor-positive breast cancer, but markers predictive of treatment failure have not been identified. Here, we generated gene expression profiles of hormone receptor-positive primary breast cancers in a set of 60 patients treated with adjuvant tamoxifen monotherapy. An expression signature predictive of disease-free survival was reduced to a two-gene ratio, HOXB13 versus IL17BR, which outperformed exi  ...[more]

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