Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

ABSTRACT: Neuroendocrine prostate cancer (NEPC) is a subset of castration-resistant prostate cancer (CRPC) and is thought to derive from prostate adenocarcinoma. However, the cellular basis responsible for Neuroendocrine differentiation (NED) is still under debate. Here, we characterized the tumor cell diversity of 6 CRPC patients using single cell RNA sequencing (scRNA-seq) and detected NED in four patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137829 | GEO | 2020/09/01

REPOSITORIES: GEO