CD48-dependent protective autophagy in conventional human T cells promotes restimulation-induced cell death resistance

ABSTRACT: Transcriptome profiling and functional analyses on expanding Tcons revealed that FOXP3 enhances expression of the SLAM family receptor CD48, which in turn sustains basal autophagy and suppresses pro-apoptotic p53 signaling. Our findings suggest that FOXP3 governs a distinct transcriptional program in early-stage effector Tcons that maintains RICD resistance via CD48-dependent protective autophagy and p53 suppression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE137931 | GEO | 2019/12/15

REPOSITORIES: GEO