Transcriptome analysis of HeLa cells knocked down for EXT1 or FBXW7 gene expression

ABSTRACT: Exostosin-1 (EXT1) is an ER-resident glycosyltransferase known to polymerize heparan sulfate chain by sequential addition of glucuronic acid and N-acetylglucosamine molecules. This reaction results in heavily glycosylated proteoglycans (PG) at the plasma membrane, which form cell-type specific complexes and play vital roles in cell-cell and cell-pathogens interactions, cell growth, plasticity and proliferation in the local tissue environment. We found that EXT1 interact with a number of intracellular proteins including FBXW7 and hypothesized that both proteins cooperate in targeted protein degradation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138030 | GEO | 2020/09/25

REPOSITORIES: GEO