IDENTIFYING KEY DRIVER GENES OF INNATE IMMUNE PATHWAYS AS NOVEL THERAPEUTIC TARGETS IN RENAL ALLOGRAFT REJECTION

ABSTRACT: Acute rejection (AR) in renal transplantation is an established risk factor for reduced allograft survival, and still occurs in 10-20% of allograft recipients despite standard of care immunosuppression. This suggests molecular pathways exist which are inadequately suppressed by current therapy. We describe for the first time, integrative network- based computational strategies incorporating genotyping data to identify key driver genes (KDGs) amongst networks of perturbed transcripts in AR, which may serve as therapeutic targets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138043 | GEO | 2020/11/03

REPOSITORIES: GEO