Dataset Information


Photoactivatable-Ribonucleotide-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP) of RNA-binding proteins (RBPs), IGF2BP1 and IGF2BP3 in the K562 CML-derived cell line

ABSTRACT: Transcriptome-wide profiling of RNA-binding by IGF2BP1 and IGF2BP3 in the K562 cell line. Binding sites are characterized by T-to-C cross-linking mutations, depth and location on transcript Overall design: Two biological replicates of PAR-CLIP are provided each for IGF2BP1 and IGF2BP3

INSTRUMENT(S): Illumina HiSeq 3000 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Bryan Chim  

PROVIDER: GSE138063 | GEO | 2020-02-10


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Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an oncofetal protein expressed in various cancers including leukemia. In this study, we assessed the role of IGF2BP1 in orchestrating leukemia stem cell properties. Tumor-initiating potential, sensitivity to chemotherapeutic agents, and expression of cancer stem cell markers were assessed in a panel of myeloid, B-, and T-cell leukemia cell lines using gain- and loss-of-function systems, cross-linking immunoprecipitation (CLIP), and  ...[more]

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