Genomics

Dataset Information

0

Photoactivatable-Ribonucleotide-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP) of RNA-binding proteins (RBPs), IGF2BP1 and IGF2BP3 in the K562 CML-derived cell line


ABSTRACT: Transcriptome-wide profiling of RNA-binding by IGF2BP1 and IGF2BP3 in the K562 cell line. Binding sites are characterized by T-to-C cross-linking mutations, depth and location on transcript Overall design: Two biological replicates of PAR-CLIP are provided each for IGF2BP1 and IGF2BP3

INSTRUMENT(S): Illumina HiSeq 3000 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Bryan Chim  

PROVIDER: GSE138063 | GEO | 2020-02-10

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE138063_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2
altmetric image

Publications


Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an oncofetal protein expressed in various cancers including leukemia. In this study, we assessed the role of IGF2BP1 in orchestrating leukemia stem cell properties. Tumor-initiating potential, sensitivity to chemotherapeutic agents, and expression of cancer stem cell markers were assessed in a panel of myeloid, B-, and T-cell leukemia cell lines using gain- and loss-of-function systems, cross-linking immunoprecipitation (CLIP), and  ...[more]

Similar Datasets

2010-01-01 | S-EPMC3268182 | BioStudies
| PRJNA574408 | ENA
2019-06-27 | GSE98465 | GEO
2020-01-01 | S-EPMC7471344 | BioStudies
2014-01-01 | S-EPMC4040666 | BioStudies
2016-01-01 | S-EPMC4889463 | BioStudies
2020-01-01 | S-EPMC7486890 | BioStudies
2020-01-01 | S-EPMC7054421 | BioStudies
2018-03-19 | GSE109604 | GEO
2020-01-01 | S-EPMC7523351 | BioStudies