Bead-based kinase phosphorylation profiling identifies SRC as a therapeutic target in glioblastoma

ABSTRACT: Here we describe a bead-based method capable of profiling tyrosine kinase phosphorylations in a multiplexed, high-throughput and low-cost manner. This approach allows for the discovery of tyrosine kinase-activating events, even when the DNA sequence is wild-type. In an effort to pilot the establishment of a tyrosine kinase activation catalog, we profiled tyrosine phosphorylation levels of 62 tyrosine kinases in 130 human cancer lines, and followed-up on the frequent SRC phosphorylation in glioblastoma. Keywords: quantitative measurements of tyrosine phosphorylation levels on tyrosine kinases

ORGANISM(S): Homo sapiens

PROVIDER: GSE13808 | GEO | 2008/12/05

SECONDARY ACCESSION(S): PRJNA110577

REPOSITORIES: GEO